VEGF Receptors and Glomerular Function
نویسندگان
چکیده
منابع مشابه
Glomerular structure and function require paracrine, not autocrine, VEGF-VEGFR-2 signaling.
VEGF is a potent vascular growth factor produced by podocytes in the developing and mature glomerulus. Specific deletion of VEGF from podocytes causes glomerular abnormalities including profound endothelial cell injury, suggesting that paracrine signaling is critical for maintaining the glomerular filtration barrier (GFB). However, it is not clear whether normal GFB function also requires autoc...
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ژورنال
عنوان ژورنال: Journal of the American Society of Nephrology
سال: 2010
ISSN: 1046-6673,1533-3450
DOI: 10.1681/asn.2010080871